The prime objectives of this study was to develop buccal tablets of trimetazidine dihydrochloride using a direct compression procedure with various bioadhesive polymers. The aim was to enhance the in-vitro release and drug release of buccal tablets. Polyvinyl alcohol, polyvinyl pyrrolidone and carbopol 934P were utilized as bioadhesive polymers in different proportions to formulate the desired buccal tablets. A total of nine formulations were prepared and optimized based on various characteristics of the buccal tablets. Compatibility studies were conducted to evaluate the compatibility between the polymers and between different formulations. A factorial design was employed with carbopol 934 and mannitol as independent variables and T50, drug release and swelling index as dependent variables. The buccal tablets were subjected to analyze for various physiochemical parameters including weight variation, friability, hardness, thickness, disintegration time, swelling studies and swelling index and in-vitro release. All these parameters were found to be within acceptable range. The development and optimization of buccal tablets containing trimetazidine dihydrochloride using bioadhesive polymers demonstrated promising results. The formulation exhibited desirable physiochemical properties, including weight variation, hardness, swelling index, in-vitro drug release. These findings indicate the potential for the buccal tablets to effectively release of the drug and enhance its delivery. Further studies are warranted to evaluate their performance in vivo and assess their therapeutic efficacy.