Background:- A common pathophysiological mechanism has been suggested as the link between diabetic retinopathy and diabetic nephropathy. However, if patients do not have diabetic retinopathy, it is very challenging to distinguish diabetic nephropathy from other glomerular disorders; the only option to do this is to take renal biopsies. Study Objective:- To comprehend the current argument concerning the frequency of retinopathy in patients with diabetes with and without diabetic nephropathy. Material and Methods:- The current study is based on a meta-analysis study design carried out on secondary published research. A midline search of the literature between 2017 and 2023 was conducted. 37 articles with related content were chosen from this search. Conclusion:- Patients with and without diabetic retinopathy exhibit various clinical and biochemical characteristics of diabetic nephropathy. The relationship between the severity of diabetic retinopathy and the severity of diabetic nephropathy and neuropathy can be used to anticipate the progression of chronic renal disease as well as the neurological repercussions in diabetic patients.