Multi particulate system has undergone a great change in past decade with a significant role in novel approaches achieving drug delivery within time. Much research was done in Pelletization process over the implementation and advanced techniques. It was found to be the technology enlightenment over accurate delivery. It delivers large pharmaceutical applications over the benefits of distinguished loading size of pharmaceutical ingredients specifically to APIs, distribution in minimum size and in-expensive to help in Targeted site delivery and to improve the drugs bioavailability. The present research aimed with the extrusion-spheronization processing formulation of the modified release gastro retentive orlistat micro particles of the pellets were subjected to dissolution. The drug release studies revealed that the formulated pellet produced desire effect.