Due to a short residence period in the upper minor intestine, oral solid drug absorption with a limited absorption window exhibits poor bioavailability with conventional dosage forms. To get over this limitation and enhance bioavailability of the drugs, CDDS (controlled drug delivery systems) with a protracted stomach holding time is employed. One can make use of gastric retention medication delivery method to extend the duration of time a drug stays in the upper gastrointestinal tract. Many efforts have been made in recent years to increase the therapeutic effectiveness and medication bioavailability orally administered dosage forms. In this situation, a variety of GRDDS (drug delivery systems of gastro retentive) have been employed to increase the therapeutic effectiveness of medications with a limited window of absorption, alkaline pH instability, solubility in acidic conditions, and local stomach activity. Several elements, including pharmaceutical considerations, physiological factors, and other factors related to patient are described together with the stomach’s physiological state. After that, we studied a number of gastro retentive techniques that have been created and refined to far, including the floating system, effervescent floating DDS such as raft forming system and gas generating system, high density systems (sinking), bio adhesive system, expanded system, ultra-porous hydrogel system and magnetic system. At the end a brief explanation of future prospective of GRDDS has being underlined.