The pathological hallmark of Parkinson’s disease is the progressive loss of dopaminergic neurons. The current treatment regime slows down the disease progression symptomatically but has numerous side effects. In this study, the anti-inflammatory and anti-oxidative potentials of ethanolic extract of Moringa oleifera leaf (MOE) has been assessed on MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinsonian mouse model. The findings of this study revealed that presence of bioactive phytochemicals in Moringa leaf imparts neuroprotective effects by modulating MPTP-induced neurobehavioral, biochemical deficits (enhanced endogenous antioxidative enzymes and abated oxidative stress markers) and regulating the expression of neuroinflammatory markers (TNF-α, NF-kB, and iNOS).