Plasmapheresis is a procedure carried out for various life threatening and debilitating diseases as a principal mode of treatment or as an adjunct with other therapies. It is a process involving extracorporeal removal of plasma from other components of blood, discarding and replacing plasma with physiological fluids. This study aimed to assess health related needs of patients undergoing plasmapheresis at Ain Shams University Hospitals. A descriptive exploratory research design was used to conduct this study. Settings: This study was conducted at dialysis unit at Ain- Shams University Hospitals. Sample: A purposive sample of 70 adult patients received plasmapheresis at mention setting. Three tools were used for data collection tool I: Patients interview questionnaire consists of two parts: (1) demographic characteristics of the patients, (2) patients' medical history. Plasmapheresis patient's knowledge Assessment Tool: Patients needs questionnaire. Results: The study showed that 57% of the studied patients were female from urban area, and 50% were married with mean age 37.05 ± 9.11 years. Also, total level of physical needs had a significant statistical positive correlation with total level of physical problems and psychological problems. The study concluded that approximately three-fifth of the studied patient had unsatisfactory knowledge level with physical and psychological needs as well more than half of patients had physical and psychological problems. Psychosocial counseling to facilitate dealing with anxiety and depression, improve patient’s mental health and social dependence.