Liver illnesses are an increasing global concern; nevertheless, there are currently no effective preventive or treatment options available, which contributes to an exceptionally dismal prognostic and high mortality rate associated with this type of disorder. Hepatoprotective is a key fitness problem in the field of modern medicine; as a result, the search for a novel effective treatment that does not have any side effects is continuing. Hepatoprotective potential of Carica papaya was evaluated against Carbon Tetrachloride induced hepatic damage on rats. Thirty six healthy albino rats were divided into six groups, each group with six rats with a weight range of 30–40 gm were selected for the experiment for a period of 14 days by using 36 rats. Biochemical Assay and Histopathological Studies of Rat Liver was performed. The Ethanolic extract of carica papaya in combination reduces the level of serum total protein specifically the elevated bilirubin levels. Single administration of CCl4 adversely protein metabolism of body there by inhibiting protein synthesis. The Ethanolic extract of carica papaya plant have the potency to increase protein synthesis and reverse the effect of CCL4.