Liver disease is a collective term for a group of disorders that damage the tissues, structures, and cells of the human liver. Many important functions are performed by the liver, so it is open to many mistakes. One of the most common causes of liver disease is inflammation, often caused by alcohol, poor diet, or malnutrition. drug-induced liver injury or liver failure is a major health crisis that challenges not only medical professionals, but also the pharmaceutical industry and the Drug Control Board. According to the American Acute Liver Failure Study Group, more than 50% of cases of acute liver failure involve idiosyncratic liver injury caused by other drugs, including hepatotoxicity caused by acetaminophen overdose (39%).The present paper deals with the hepatoprotective activity of hydro-alcoholic extract of Abutilon indicum (Stem) against paracetamol induced liver toxicity in albino rats. The results indicate that hydro-alcoholic extract showed significant hepatoprotective activity as compared to the hepatotoxic control at the dose of 200 mg/kg.