Introduction: Traditional medicine is the sum of knowledge, skills, beliefs and experiences used in the maintenance of health and in the diagnosis, prevention, improvement or treatment of physical and mental illness. Drugs can damage the liver cells in their original form or in various intermediate stages. Objective: Effects of Ethanol extract of Turnera aphrodisiaca in treatment of Diclofenac induced hepatotoxicity in lab animals. Methods: Group I was given a 2% w/v acacia solution, Group II was given 150 mg/kg/b.w. of diclofenac, Group III received 150 mg/kg/b.w. of diclofenac and standard silymarin, and Group IV and V received 200 and 400 mg/kg b.w. of EETA. Animals were sacrificed on the 29th day and their livers were separated, cleaned, and preserved in 10% neutral formalin for histopathological research.