To evaluate the hepatoprotective activity of Methanolic extract of Indigofera prostrata against paracetamol and alcohol induced liver injury in experimental rats. Methanolic extract of Indigofera prostrataat doses of 200mg/kg and 400mg/kg body weight, p.o., was administered for 15 days in paracetamol (500gm/kg, orally) and 30% alcohol (1.5 ml/rat / twice a day) for 15 days intoxicated rats and compared with silymarine (25 mg/kg, p.o.) treated rats. Biochemical parameters, alkaline phosphatase (ALP), serum glutamic oxalacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and total bilirubin (TB) levels were recorded to investigate the degree of improvement in the conditions of the rabbits. The liver was removed, washed with normal saline and preserved in 10% formalin and used in histopathological studies of hepatic architecture by microscopy. Phytochemical screening of the extract was also carried out. The levels of biochemical parameters were increased in paracetamol and alcohol intoxicated rats when compared with the normal group. The extract, at doses of 200 and 400mg/kg, exhibited significant (p < 0.001) reduction in biochemical parameters (ALP, SGOT, SGPT and TB). Hepatoprotective activity was also confirmed by histopathological findings. Furthermore, the phytochemical profile of the extract revealed the presence of tannins, alkaloids, saponins and flavonoids. These results suggest that Indigofera prostrata extract possesses significant hepatoprotective effect against paracetamol and alcohol induced hepatotoxicity and this may be due to the presence of flavonoids and tannins.