Berries (black, blue, red and rasp) are among the better plants with medicinal value due to its higher content of bioactive phenolic compounds. The present study was performed to find out the effectiveness of white, red, and black mulberry in protection against CCl4-induced-hepatotoxicity in rats. The total phenolics, flavonoids, anthocyanin, and carotenoids as well as the total antioxidant capacity of white, red, black mulberry were identified. To accomplish the current study forty-two male rats were divided into six groups, of 7 rats each. Group 1, kept as the negative control group fed on the basal diet alone. Groups 2, 3, 4, 5 and 6 were intraperitoneal injected (IP) once a week for six weeks with 1 ml/kg b.wt of CCl4 to induce liver toxicity. Group 2, kept as a positive control group and fed on the basal diet only, while hepatotoxic groups 3, 4, 5 and 6 were nourished on a supplemented basal diet with 5% of dried white, black, red mulberries and their mixture in proportion to 1:1:1, respectively. In comparison to untreated hepatotoxic-rats (positive control group) fed on the basal diet alone, feeding hepatotoxic-groups on an enriched diet with the three different berry colors caused a significant increased (p<0.05) in body weight gain, serum levels of HDL-c, total protein and albumin, activities of antioxidant enzymes (CAT, SOD, GSH and GPx), and decreased in the activities of AST, ALT and ALP enzymes, and serum levels of total, direct and indirect bilirubin, total lipids, cholesterol, triglycerides, LDL-c, VLDL-c and MDA. In addition, histopathological examination confirmed the results of biochemical analysis and showed an obvious improvement in the liver sections of hepatotoxic-rats fed on the enriched basal diet with three different berry colors. Finally, the existing study demonstrated that different colors of berries could improve the liver functions and activity of antioxidant enzymes by eliminating the deleterious toxic effect of CCl4, especially with their mixtures.