Infection may arise if the human body's defense mechanism is compromised or if the concentration of germs is excessively high. Medical professionals classify infectious sickness as any condition in which signs and symptoms become clinically evident as a result of the body's response to invading invaders. Bacterial illnesses were among the most feared forms of infectious disease. In recent years, various studies have shown that the prevalence of this condition has increased in India. It is also becoming more difficult to treat fungal infections using antifungal medications. In addition, the high expense of these medicines in underdeveloped nations like India was a major hurdle. The inability of existing available medication draws our attention toward the development of alternative therapeutic options. In this paper, we have highlighted the role of promising herbal bioactives that can prove to be beneficial for the prevention and management of skin infections.