Anomalous epigenetic modifications are described in different pathological conditions, which includes Type 2 Diabetes, cardiovascular disease, neurodegenerative disease, obesity and cancer. The recent progress in Epigenetic modification studies and ability to reverse of epigenesist makes them an encouraging target. e.g., treatment of Diabetes. Hence, several epigenetically active compounds studied for their role in treatment of several diseases including diabetes. Many Flavonoids which are phytochemicals present in plants have ability to alter epigenetic cellular mechanisms. In this review, to facilitate the compilation of the sources, we studied biosynthesis, characterization, pharmacokinetics, antioxidant and anti-diabetic activities of Hesperidin conventional and online-literature that comprises the electronic search (Sci Finder, Pubmed, Google Scholar, Scopus, and Web of Science etc) and books on Diabetics /Epigenetics were studied. These Flavonoids that are natural phenol compounds has been found in plants and can be sub-characterized into subclasses which affect the two top characterized epigenetic mechanisms viz., DNA methylation and Histone Modification. High intake of Dietary flavonoid intake helps to reduce the threat of cardiovascular disease which includes Diabetes Mellitus.