Heterocyclic compounds are one of the fastest developing branches of synthetic chemistry, it grabs more attention because of their high existence in nature as well as their most important role in the creation of useful materials and drugs. Compounds such as carbon, hydrogen and methane does not show that much activity against microbes but heterocyclic compounds such as three-, four-, five-, six- and higher-membered rings containing drugs act as antimicrobial agents. There are different types of activities shown by the heterocyclic compounds. In this review paper some famous commercial drugs such as amphotericin B, amoxicillin, cephalexin, ceftriaxone, ciprofloxacin, fosfomycin, ketoconazole, miconazole, levofloxacin, penicillin, sulconazole, Voriconazole etc. along with their mode of action, dosage, and CAS ID will be discussed.