Background: The role of CGF has been established in the formation of the bone around dental implants. It has been said to form bone either in combination with xenograft/allograft or alone by itself. It is also seen that CGF helps in the improvement of bone quality around dental implants. Aim: The present clinical study was aimed to histologically evaluate the impact of CGF, a new generation platelet derivative, on healing following sinus floor augmentation during maxillary sinus lift surgical procedures. Methods: The present study assessed 18 subjects with bilaterally complete or partially edentulous maxilla where implants were placed following the split-mouth protocol. After sinus membrane lift, CGF was placed on one side and bovine xenograft on