Infertility is defined as one year of unprotected coitus without conception. Primary infertility applies to those who have never conceived, whereas secondary infertility designates those who have conceived sometime in the past. In spite of many investigatory tools available, endometrial biopsy remained the most important tool as endometrial histology is a sensitive indicator of ovarian function. The present study was conducted in the department of pathology of NKP Salve Institute of Medical Sciences and Research Centre, Nagpur. Fifty specimens of endometrial biopsy received from females with complaints of infertility (both primary and secondary) who reported in the department of obstetrics and gynecology were included in the study. In the present study various endometrial abnormalities like anovulatory endometrium and luteal phase defect were noted which formed etiological basis of many cases of infertility. Endometrial tuberculosis and hyperplasia formed a minor group of cases. Observing the glycogen deficiency is also useful. In the present study glycogen deficiency is mainly seen in the luteal phase defect, concluding that the cause of glycogen deficiency is secondary to histopathologic immaturity of endometrium.