Since axillary lymph node involvement is the main cause of breast cancer surgical morbidity, identifying lymph node metastasis predictions might improve clinical outcomes. To predict the association of axillary lymph node positivity with involvement in breast cancer by using histopathological indicators. Material and Methods: A retrospective study was performed on 50 breast cancer patients who had modified radical mastectomy at Pt. BDS Post-Graduate Institute of Medical Sciences, Rohtak, India from March, 2019 to March, 2021. Tumour size, histological type, grade, lympho-vascular invasion, hormonal and Her2/status, Ki67 index, and molecular subtype were acquired from histopathological reports. The association between tumour features and lymph node status was assessed. Results: Age at diagnosis, lymphovascular invasion, Her2/neu status, and Her2/neu-enriched molecular subtype were significantly associated (p<0.05) with lymph node positive. Nodal metastases [54% (27/50)] and high Ki67 index [24% (12/50)] associated with lymph node positivity in total number of patients. Conclusion: This study predicted breast cancer axillary lymph node involvement using lympho-vascular invasion, age at diagnosis, Her2/neu status, Her2/neu-enriched molecular subtype, and Ki67 index. This data may be utilized for breast cancer diagnosis and treatment.