Background: Traumatic brain injury (TBI) is a significant public health concern with diverse outcomes and lasting impacts on individuals. Rehabilitation following TBI aims to maximize cognitive, functional, and physical capacity for independent post-injury life. The holistic approach, emphasizing physical, psychological, social, emotional, and motivational aspects, is considered essential for quality care in TBI rehabilitation. However, its implementation remains inconsistent, possibly due to various complex factors. Health practitioners, including nurses, radiologists, and pharmacists, play crucial roles in TBI management. Objective: This review aims to explore the perspectives of health practitioners on the role of holistic practice in TBI rehabilitation, identify current practices and perceptions regarding holistic approaches, and assess the benefits and challenges of incorporating holistic practices from the perspectives of nursing, radiology, and pharmacy professionals. Conclusion: The implementation of holistic practices in TBI rehabilitation remains inconsistent, highlighting the need for further research and efforts to enhance understanding and application. Health practitioners, including nurses, radiologists, and pharmacists, play vital roles in TBI management. The influence of rehabilitation services and settings underscores the importance of tailored, comprehensive care across the continuum of TBI recovery. Improved understanding and application of holistic practices in TBI rehabilitation are crucial for enhancing patient outcomes and addressing the complex needs of individuals with TBI.