The emergence of SARS-CoV-2 causing COVID-19 led to a global health crisis, prompting extensive research into diagnostic methods and potential treatments. Various approaches, including molecular techniques and thermal scanning, have been employed for accurate identification of COVID-19 cases. However, no authorized drug or vaccine for SARS-CoV-2 has been approved, prompting investigations into alternative treatment options. Curcumin, a natural compound with diverse pharmacological effects, shows promise as an antiviral agent. Molecular docking studies reveal its ability to bind to the spike proteins of SARS-CoV-2 and SARS-CoV, suggesting potential therapeutic implications. In this comprehensive review, we explore the intricate structure of SARS-CoV-2, its transmission routes, primary symptoms, and the role of curcumin as a potential treatment targeting the viral spike proteins. Despite ongoing challenges, ongoing research and advancements offer hope for effectively combating COVID-19