3D bioprinting with hydrogels has emerged as a promising technology for creating complex and functional biological structures with potential applications in regenerative medicine, tissue engineering, and drug discovery. Hydrogels offer excellent biocompatibility, porosity, and mechanical properties, making them ideal materials for bioprinting. The field of 3D bioprinting with hydrogels has seen significant progress in recent years, with advancements in technology and materials enabling the creation of increasingly complex structures with higher resolution and precision. However, there are still challenges that need to be addressed, such as the need for developing bioprinting techniques that can print larger structures with sufficient mechanical stability and cell viability, as well as regulatory challenges associated with the use of bioprinted constructs for clinical applications. Nonetheless, the field of 3D bioprinting with hydrogels presents several opportunities for advancing the field of regenerative medicine and personalized healthcare. This review provides an overview of the properties, types, methods, advantages, and disadvantages of hydrogels for 3D bioprinting, as well as the current progress, future perspectives, challenges, and opportunities of this exciting field.