Rabies lyssavirus is a bullet-shaped, negative-sense, single-stranded RNA virus of the Rhabdoviridae family. There is no treatment for the symptomatic illness. Fatality rate of rabies is close to 100% for non vaccinated people.The Rabies transmitted through the saliva of infected animals. Though the vaccines are commercially available in market,this scientific study was designed to develop a vaccine for rabies in silico analysis. The protein sequence of Rabies virus was retrieved from Uniprot.B-cell and T-cell epitopes were identified and further screened for allergenicity, antigenicity, simulation and the vaccine tertiary structure was designed.