Allergic diseases encompassing asthma, allergic rhinitis, atopic dermatitis, and food allergies, pose a significant global health burden. Toll-like receptor 4 (TLR-4) activation, endotoxin exposure, monocyte chemoattractant protein (MCP-1), thymus and activation-regulated chemokine (TARC), and interleukin-5 (IL-5) have emerged as key factors implicated in the pathogenesis of allergic diseases. This study aimed to explore the roles of these factors in allergic diseases by analyzing their correlations and associations. IgE, IL-5, and TARC levels were categorized into two groups (Group 1 and Group 2),based on high and lowigE levels and their correlations with TLR-4, endotoxin, and MCP-1 were examined. The results showed a significant difference in IgE levels between the groups, but no significant correlations were observed between IgE and the other factors. IL-5 levels exhibited a significant difference between groups, and positive correlations were found with TLR-4, endotoxin, and MCP-1 in Group 1. TARC levels also differed significantly between groups, with positive correlations observed in Group 2. These findings highlight the complexity of allergic diseases and suggest the involvement of TLR-4, endotoxin, MCP-1, TARC, and IL-5 in different contexts. Further investigations are warranted to elucidate the underlying mechanisms and explore the therapeutic potential of targeting these molecules in allergic diseases