The coronavirus (Covid-19) has infected over 60 million people with over 1.5 million deaths worldwide. Saudi Arabia is one of the infected countries where 357,000 cases were recorded, 347,000 were discharged or cured and 5,907 deaths were reported as per the World Health Organization by the first of December 2020. While discussing the crisis COVID-19 we must mention the immune system and how it is supporting us. The immune system is a complex and sophisticated network of specialized organs, tissues, cells, proteins, and chemicals that have been established to defend the host against several pathogens, including viruses, bacteria, fungi, parasites, and cancer cells. Antioxidants are one of these immune promoters. They're often referred to as free radical removal.” To promote a wide range of positive results, nutrition practitioners advise a high intake of antioxidants regularly in the form of food. Vegetables and fruits are considered to be healthy, they are rich sources of antioxidants. This is a systematic review of clinical and laboratory research assessing the effect of antioxidants in the coronavirus disease crisis of 2019 on the immune system. We used the "Immune system"," COVID-19", "Oxidative stress" and "Antioxidants" keywords and collected the data from PubMed. And Abstracts were initially screened to include only articles that examined the association between Immunity and Antioxidants. So, as we recognize from the articles, antioxidants may help in preventing this mechanism and lead to reducing the free radicals and enhancing the functioning of immune cells to fight the virus.