Oral Leukoplakia is defined as, “a predominantly white lesion of the oral mucosa that can't be characterized as any other definable lesion; some oral leukoplakias will transform into cancers.” Treatment and management of patients with oral precancerous lesions are determined by evaluating their risk for malignant progression which is 1.5% to 34% for oral leukoplakic lesions. It is crucial that clinicians embrace the importance of early detection and treatment of premalignant lesions. Surgical removal with cold-blade scalpel excision or electrocautery excision significantly reduces the risk of transformation of the lesion. Laser surgery has shown to exhibit several advantages over scalpel for many procedures. This study sought to determine if there was a difference in the intensity of pain, hemostasis and rate of wound healing/ or scar formation following excision with scalpel when compared to excision done with a CO2 laser.