Coronavirus disease has proved much more than a health crisis. It has severely affected social behaviour, disturbances in psychology, undue fear, loss of concentration and economic crisis. It has affected every aspect of human life around the globe. Apart from playing with the health of people, this invisible enemy has also posed the danger of an unprecedented loss to human health, societal interaction, and harmony. Its most adverse impact has been on the vulnerable population worldwide, which comprises of immigrants, pregnant women, new-born babies, homeless people, refugees, and people below the poverty line. The hollow healthcare system in the rural areas became a major issue, particularly in countries with high population density. Densely populated countries with major proportion of vulnerable communities got adversely affected by the restrictions on the mobility, social distancing, self-isolation, lockdown of all public and private institutions, shortage of care takers and unavailability of social workers. The whole global supply chain was disrupted due to which the vulnerable population in both developed and developing countries being adversely affected. The present study aims at having a theoretical examination of the ways through which this global disease affected the vulnerable population across the world.