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ISSN 2063-5346
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IMPACT OF EARLY INTERVENTION STRATEGIES ON OUTCOMES IN SEPTIC SHOCK PATIENTS: A PROSPECTIVE OBSERVATIONAL STUDY

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Abdullah Faisal Abdul Rahman Al-Thabiti, Saeed Jamman Alghamdi, Mohammed Saeed Alharthi, Mohammed Hammad Althomali, Fayez Jaber Dhifallah Al-Jaeed, Tasnim Ahmed Siam, Salwa Salem Almajnouni, Mohammed Meshal Khalf Alotaibi, Khorssan Ali Awig Alsharyah, Mubarak Abdullah Mubark Alharbi
» doi: 10.53555/ecb/2022.11.6.115

Abstract

Sepsis shock is one of the main causes of death worldwide, having mortality rates that are estimated to be at least 20% and above 50% for those with the condition. This observational research study aimed to identify critical care for sepsis in its early stages can lead to better clinical outcomes. Researchers randomize the distribution of 100 patients older than 18 years into the study within the next 18 months. The prompt antibiotic administration and the strict adherence to sepsis treatment protocols all fall within the early intervention measures. The primary outcome was a 28-day mortality rate, and organ dysfunction, as well as ICU stay, were regarded as secondary outcomes. The findings of the research demonstrated conclusively improved outcomes both short-term and long-term, particularly about survival, for patients treated early within a few days after the onset of symptoms. Lesser duration of intervention together with obedience to the protocol, for its own sake, was found to be of significant implication on the survival of the patients. There was a positive association among the mentioned subgroups consistent with their age, race, sex, and clinical characteristics. Tackling obstacles to early intervention implementation can be done through data collection centers and nurses sufficient staff, quality improvement, and sustaining the program. The learning from the undertaken study shows the criticality of immediate actions in the early stage of the disease for lowering sepsis death and its complications. Central aspects comprise not only early antibiotic therapy but also following the recommended treatment guidelines based on the evidence.

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