Sepsis is a life-threatening condition that requires prompt recognition and intervention to improve patient outcomes. Pharmacists play a crucial role in the management of sepsis by providing medication therapy management, antimicrobial stewardship, and supportive care interventions in the emergency department (ED). This review article aims to explore the impact of pharmacist-led interventions on sepsis outcomes in ED settings. A comprehensive search of electronic databases was conducted to identify relevant studies evaluating the role of pharmacists in sepsis management in the ED. The findings suggest that pharmacist-led interventions, such as protocol-driven antibiotic therapy, fluid resuscitation optimization, and medication reconciliation, have a positive impact on sepsis outcomes, including reduced mortality rates, length of stay, and healthcare costs. Collaborative efforts between pharmacists, physicians, and other healthcare providers are essential to optimize sepsis care in the ED. Future research should focus on the development of standardized protocols and guidelines for pharmacist involvement in sepsis management to further improve patient outcomes.