Background Nursing staff are exposed to numerous stresses that affect their psychological status. no study has examined the depression level and coping strategies among nurses in Saudi Arabia especially nursing. Depression and anxiety are common conditions with prevalence ranging between ten to twenty percent in the general population for any twelve month period from work. Depression in the working age population is estimated to cost $12 billion annually in medical care and approximately $44 billion annually in lost productivity. Mental health affects physical health, job performance and healthcare utilization. Stress, depression and anxiety disorders contribute to absenteeism and lack of confidence. Nursing are exposed to many stressors, such as the burden imposed by expectations of a high degree of professionalism, responsibility for patient well-being and maintenance of relationships with patients and health workers, depression among nurses during the COVID-19 pandemic in the Saudi Arabia are not well described and their modifiable causes are poorly understood. Depression is an emotional disturbance that leads to deterioration of abilities and daily activities. Aim of study: To assessment Impact of Prevalence of depression among nurses in major hospitals during the COVID-19 outbreak in Makkah Al-Mukarramah Saudi Arabia 2022. Methods this was a Cross-sectional study among nursing in major hospitals during the COVID-19 outbreak in Makkah Al-Mukarramah Saudi Arabia , this study has be conducted only 2 major hospitals in ministry of health inside the Makkah Al-Mukarramah city (in King Abdul-Aziz Specialist Hospital and King Faisal Hospital), a sample size through the epi program was (200) nurses. The researcher has been using a questionnaire covering socio-demographic data and Patient Health Questionnaire-9 (PHQ-9). Results: prevalence of depression in the nursing is (19.0%). 38 out of the 200 respondents met the PHQ-9 negative criteria for depression. show that X2 (47.2) and is a significant while p-value =0.001. Of the 200 participants 66 (33.0 %) scored into the minimal depression category, also scored into the mild depression category, (29.0%), Conclusion the studies demonstrates of existing evidence confirming the incidence of depressive disorders symptoms among nurses during the work hours and also the studies demonstrates that depression symptoms are common among nursing; the nurses-patient relationship issue is particularly stressful.