Background The early referral to palliative care (PC) represents a successful value-based model with proven benefits regarding the quality of life and clinical outcomes for advanced cancer patients and their caregivers. Yet, its provision remains typically confined to the last weeks of life as per the historical, late palliative care model. Advance Care Planning is an iterative process of discussion, decision-making and documentation about end-of-life care. Advance Care Planning is highly relevant in palliative care due to intersecting clinical needs. To enhance the implementation of Advance Care Planning, the contextual factors influencing its uptake need to be better understood. The stigma according to which palliative care represents end-of-life care has been identified as the root of the problem. Aim of the study: To Assessment the impact of Public awareness perception of palliative care and advance care planning attitudes in primary health care in Makah al-Mokarramah City, Saudi Arabia 2022. Method: Cross-sectional descriptive study has been conducted among Population in the primary health care centers in Makkah Al-Mokarramah at Saudi Arabia, the period from the April to June, 2022. Self-administered questionnaire is designed based on previous studies and frameworks Assessment of the Public knowledge, attitudes and perception of palliative care and advance care planning attitudes in primary health care. The total sample has been (200) patients. Result: show regarding age majority of the study groups were in the age range of (>50) years were (28.0%), regarding the gender many of the respondents were male (54.0%) while female were (46.0%). regarding the Marital status, the majority of the respondents were married status were (42.0%) the occupation the majority of the respondents answers Yes were (76.0%) while No were (24.0%), regarding the duration of palliative care and advance care the majority of the respondents in from (5-10) were (44.0%) while from (<5and >10) were respectively (28.0%). Conclusion: Factors influencing the uptake of Advance Care Planning in palliative care are complex and multifaceted reflecting the diverse and often competing needs of patients, health professionals and legislature and health systems. Large population-based studies of palliative care patients are required to develop the sound theoretical and empirical foundation needed to improve uptake of Advance Care Planning in this setting .