Background: While the distribution of schistosomiasis has changed over the last fifty years and there have been successful control programmers, the number of people estimated to be infected or at risk of infection has not been reduced. Today, 85% of the numbers of infected people are estimated to be on the African continent where few control efforts are made. In terms of disease burden, there is therefore a growing discrepancy between sub-Saharan Africa and the rest of the world. WHO has now developed a dual strategy for the control of schistosomiasis: a strategy for morbidity control adapted to the public health context in high burden areas, and a strategy to consolidate control in areas where a low endemic level has been reached and elimination may be feasible. Aim of the study: To assessment the awareness regarding schistosomiasis signs, symptoms, transmission and Prevention among health care workers at the primary healthcare in Makkah City at Saudi Arabia 2022. Methods: This is a cross-sectional study in which (200) respondents aged <30years More than 60 years from Makkah City communities along were interviewed using a structured questionnaire discussions were also conducted descriptive statistics were used to determine the frequency of responses for each question posed and Chi squared tests used to determine the associations between demographic variables and variables of interest. conducted about the awareness regarding schistosomiasis signs, symptoms, transmission and Prevention among health care workers at the primary healthcare in Makkah City, during the May to September, 2022. Results: awareness of the participants among Signs and symptoms results the majority of participant had high information were(36.0%) While no statistical significant relation while Chi-square X2 1.720and P-value = 0.423. awareness of the participants among Transmission results majority of participant had average information were(45.0%) While a statistical significant relation while Chi-square X2 12.520 and P-value = 0.002. Conclusion: The awareness of schistosomiasis, a disease which is still affecting a large number of poor people in the developing world, deserves more and renewed attention and commitment, particularly in Saudi Arabia. Simple, but sustained control measures can relieve an underestimated and surely unnecessary disease burden in high transmission areas.