Background: Malaria is an infectious disease caused by a protozoan parasite species belonging to the genus Plasmodium. There are five Plasmodium species that affect humans. The female Anopheles mosquito is a vector that can carry the parasite and transmit the disease from an infected individual to a healthy one. The major Anopheles species that transmit the malaria parasites in Saudi Arabia, malaria morbidity has reduced significantly in most regions of Saudi Arabia, but it is still a serious issue. Saudi Arabia and Yemen are the only two countries in the Arabian Peninsula that are yet to achieve malaria elimination. This study assessed Impact of the knowledge of Malaria fever causes and symptom among patients attending in the Primary health care at Saudi Arabia 2022. More than 80% of the total populations are at risk of malaria in the 22 countries in Asia and the Pacific. South Asia alone is home to an estimated 1.4 billion people at risk of contracting malaria. Utilization of malaria interventions are influenced by, among other things, the level of knowledge and attitude that the community has toward the infection as well as the available interventions. This study assessed malaria knowledge, attitudes, and practices on malaria infection and interventions in Saudi Arabia. Aim of the study: To assessed Impact of the knowledge of Malaria fever causes and symptom among patients attending in the Primary health care at Saudi Arabia 2022. Methods: Across sectional descriptive study conducted among patients attending in the Primary health care at Saudi Arabia, during the January to March, 2022, the Sample size of patients. Our total participants were (300). Results: shows that the majority of participants approximately (39.0%) were aged from 35-50 years of age, followed by <25 years and >50 were (15.0%), sex, more than half of participant (58.0%) were male, income, most of participants (50.0%) were have more than >10000 SR monthly, regarding the educational level, this table reveals that approximately of participant (30.0%) were university while primary were (29.0%), regarding the Sources of knowledge about dengue fever the majority of participant Communication Web-sites were (31%). Conclusion: knowledge of Malaria fever causes and symptom among patients in malaria-endemic rural areas of the Saudi Arabia. There is a need for the implementation of interventions that will focus on increasing knowledge of malaria prevention and causes and symptom as well as promoting regular bed net usage and healthcare seeking behaviors.