Background: Foot ulceration is the most common lower-extremity complication in patients with diabetes mellitus. Despite lower-limb amputation being common among patients with diabetic foot ulcers, few studies have qualitatively investigated the patients' perspectives. Diabetic foot ulcers (DFUs) and ulceration are complex and lifelong problems for patients with diabetes which dramatically increase mortality rates. Nowadays, diabetes constitutes a significant medical, social and economic problem. According to the World Health Organization in 2025 the incidence of this disease will double in both developed and developing countries, increase Incidence of diabetes depending on the region. Costs for healing ulcers are high and even higher for ulcers resulting in amputation, due to prolonged hospitalization, rehabilitation and need for home care and social service for disabled patients, also negatively influence patients’ psychosocial functioning and require multidisciplinary support from a therapeutic care team and psycho-social team. Aim of the study: To Assessment Patient perspectives on the physical, psycho-social, and financial impacts of diabetic foot ulceration and amputation in Makkah Al-Mokarramah , Saudi Arabia2022. Method: A cross-sectional, was conducted in in 3 hospitals, in Makkah, within Multidisciplinary Diabetic Foot Clinics and/or Vascular Surgery Departments. impact of the Patient perspectives on the physical, psycho-social, and financial impacts of diabetic foot ulceration and amputation, also a self-administered questionnaire was designed and has been send to the study participants, was performed between June 2022 and March 2022. Our total participants were (200). Results: shows most of the participants were (31.0%) in the age group 40-50 years, gender the majority of them were male (52.0%) level of education the majority of participant are University degree were (47.0%), the Number of children the majority of participant more than five were (32.0%) the nationality most of participants Saudi were(65.0%) Conclusion: These data illuminate common on the physical, psycho-social, and financial impacts of diabetic foot ulceration and amputation problems across and role of the social worker to avoid the potential Social and psychological impact, also to minimize the impact of future the Social and psychological service, patient their social activity is also reduced by the need for constant diabetes control, for these many reasons the social worker and psycho-social team has an important role