Evidence-based practice is crucial in ensuring that nursing care is based on the best available evidence, leading to improved patient outcomes and quality of care. The article discusses the challenges and barriers faced by nurses in implementing evidence-based practice, such as lack of time, resources, and knowledge. Strategies for overcoming these challenges are explored, including the importance of creating a supportive organizational culture that values research and encourages continuous learning. Furthermore, the article delves into the methods and tools used to evaluate the effectiveness of evidence-based practice in nursing, such as audits, surveys, and outcome measurements. The importance of ongoing evaluation to ensure that practice remains evidence-based and up-to-date is emphasized. Various models and frameworks for evaluating evidence-based practice are discussed, providing nurses with practical guidance on how to assess and improve their practice. Moreover, the article highlights the impact of evidence-based practice on patient outcomes, nurse satisfaction, and healthcare quality. By implementing evidence-based practice, nurses can enhance their clinical decision-making skills, improve patient safety, and contribute to a culture of continuous quality improvement in healthcare settings. The role of leadership in promoting evidence-based practice and fostering a culture of inquiry is also explored. In conclusion, this review article underscores the significance of implementing and evaluating evidence-based practice in nursing. By embracing evidence-based practice, nurses can enhance the quality of care they provide, improve patient outcomes, and contribute to the advancement of the nursing profession as a whole.