This review article explores the implementation and evaluation of nurse-led palliative care programs in healthcare settings. Nurse-led palliative care programs play a crucial role in improving the quality of life for patients with serious illnesses by providing comprehensive and compassionate care. The article synthesizes current literature on the benefits, challenges, and best practices associated with nurse-led palliative care programs. It examines the impact of these programs on patient outcomes, caregiver satisfaction, healthcare costs, and healthcare system efficiency. Furthermore, the review discusses the role of nurses in delivering palliative care, the necessary training and skills required, and the importance of interdisciplinary collaboration in providing holistic care. The article also addresses the barriers to implementing nurse-led palliative care programs and suggests strategies for overcoming these obstacles. Overall, this review aims to provide insights into the effectiveness of nurse-led palliative care programs and their potential to enhance the quality of end-of-life care for patients.