Healthcare-associated infections (HAIs) are a significant concern in healthcare settings worldwide, leading to increased morbidity, mortality, and healthcare costs. This review article explores various strategies aimed at reducing HAIs and improving patient safety. The implementation of effective infection control measures, such as hand hygiene protocols, environmental cleaning, and antimicrobial stewardship programs, plays a crucial role in preventing HAIs. Additionally, the use of surveillance systems and data analytics can help identify trends and outbreaks, enabling healthcare facilities to respond promptly and effectively. Furthermore, education and training programs for healthcare workers are essential in ensuring compliance with infection control practices. This review also discusses the role of technology, such as electronic health records and telemedicine, in enhancing infection prevention efforts. Overall, a multifaceted approach that combines various strategies is necessary to successfully reduce HAIs and promote patient well-being in healthcare settings.