The goal of this work was to create solid lipid nanoparticles that contained 13 mg of both doxorubicin and curcumin per ml of the SLN dispersion. Size, zeta potential, entrapment efficiency (EE), and drug loading (DL) were used to characterize the SLN after they were synthesized using a hot homogenization procedure. The characterization of the created formulation enabled for the conclusion to be made that the SLNs were successfully synthesized and amorphous, showing that curcumin and doxorubicin were present in a solubilized condition. Furthermore, compared to free curcumin's first order release, the generated Curcumin, Doxorubicin Loaded Solid Lipid Nanoparticles displayed a zero order release, illuminating the controlled release property of the substance.To the best of our knowledge, it is the most potent combination of high drug loading and the largest increase in curcumin and doxorubicin solubility in an aqueous medium (1.4×106 times increase compared to 11 ng/ml in water for free curcumin).The results showed that the LOD and LOQ were 1.95 ng/ml and 19 ng/ml, respectively. Total recovery was 85% or more. At LQC, MQC, and HQC, individual recoveries were 80.18, 87.18, and 84.42%, respectively.The intra-day accuracy for QC samples with a precision of less than 2% was 99.43-102.21%, while the inter-day accuracy was 99.47-106.83%.