In recent days, herbal medicines and its bioactive compounds have gained global attention owing to its lesser side effects, lower cost and easy availability. Diabetes mellitus is a chronic metabolic disorder with multi-factorial complications affecting the quality of life. Though there are numerous medications on the market for the treatment of diabetes, they are not free from its side effects, drug dependency and poses high economic burden.The focus of this research is to conduct an in-silico computational analysis of phytochemicals in the traditional Siddha formulation Maruthampattai Kudineer (MPK), which is extensively used to treat diabetes. AutoDockTools were used to prepare and optimize the ligand structures. All of the compounds were docked using Autodock Vina. The formation of a hydrogen bond between phytocomponents and the target's core amino acids (Asp568, Tyr709, Glu771, Asp392, and Arg428) will inhibit the action of the target protein enzyme alpha-glucosidase (PDB ID:4J5T), which is involved in the breakdown of starch to release sugar moieties that induce blood glucose. As a result, phytocomponents that inhibit the target enzyme alpha-glucosidase could be used as a possible targets for diabetes management.The bio-active compounds found in the Siddha formulation MPK have considerable binding to the target alpha-glucosidase (PDB ID: 4J5T), according to the results of the computational research.