Diabetes mellitus (DM) is a collection of metabolic changes impacting not just glucose but also protein and lipid metabolism. Treatment may involve a combination of several approaches, such as oral and injectable drugs, dietary and lifestyle modifications, exercise, and weight management. Herbal medicines are gaining paramount importance due to high lever of safety and wide efficacy margin. Siddha system of medicine pioneers the art of managing metabolic disorders due to its versatile nature of preparations. One such formulation is Mega sanjeevi chooranam comprises of 10 herbal ingredients prescribed in the siddha system for managing diabetes mellitus. Hence the present investigation aimed at exploring the target-specific binding potential of the phytotherapeutic leads retried from the ingredients of the formulation Mega sanjeevi chooranam against the targets alpha-amylase and alpha-glucosidase using molecular docking studies.