Diabetes affects a large population of the globe and is considered as a leading cause of death. Many synthetic and natural inhibitors have been developed for diabetes treatment. Herein, we report the potential antidiabetic activity of 2-((1H-benzo[d]imidazol-2-yl)thio)-N-(4- oxothiazolidin-3-yl)acetamide benzimidazole derivatives, 2-(((1H-benzo[d]imidazol-2- yl)thio)methyl)-5-methyl-1,3,4-oxadiazole) benzimidazole derivatives against the protein namely PDB: 3TOP.