Background: Molecular structures hold a wealth of knowledge that can be applied further. The information was decoded using a traditional Quantitative Structure-Activity Relationship (QSAR) approach based on the descriptors. A mono substituted series of Glucokinase- Glucokinase Regulatory Protein Inhibitors (GK-GKRP/GCKR) was the subject of the study. AIM: A new chemical will be created using this knowledge. To determine the suggested compound's binding pattern, docking tests will be carried out.