Antibiotic resistance profile, the incidence of extended-spectrum β-lactamases and metallo-β-lactamases among Escherichia coli and K. pneumonia isolates that showed multi-drug resistance of beef samples obtained from abattoirs in Abraka and Agbor, Delta State, Nigeria. A hundred samples of beef specimens were obtained of which fifty samples were obtained from meat samples from different abattoirs located in Abraka and Agbor using a well-labeled sterile swab stick. Thirty-six swab samples comprising 16 samples from freshly butchered meat, 10 from the apron and 10 samples from the meat seller's tables were aseptically collected and bacteriologically analyzed following standard procedure. The bacterial isolates most prevalent were Escherichia coli, Staphylococcus aureus, and Klebsiella pneumonia. The zone of inhibition pattern on bacterial isolates from the different abattoirs showed (9) resistant Klebsiella pneumonia, (2) intermediate, and (3) sensitive isolates. Similarly, Escherichia coli were (3) resistant, (4) intermediate, and (5) sensitive isolates. Twelve isolates that were resistant were selected for the combined disk test. The difference in zones of inhibition of combined disk test on meropenem-resistant organisms from samples shows (2) positive Klebsiellasp and (1) Escherichia coli with values ranging from 10-15mm. A total of 2, E. coli isolates and 6, K. pneumonia isolates were found to be resistant to meropenem with IZDs of ≤ 23mm or ≤ 27mm. Only 6 (10%) isolates of E. coli and 4 (12%) isolates of K. pneumoniae were confirmed to be MBL producers. Conclusively, this study shows that abattoirs are reservoirs for food-borne pathogens that are multidrug-resistant in nature