Purpose: To determine IL-6 levels after PRP administration in Wistar rats with partial hepatectomy (PH). Methods: An experimental study with post-test only control group design that conducted at INA Lab Padang Laboratory and Biomedical Laboratory, Faculty of Medicine, Andalas University from March to May 2023. Eighteen Wistar rats were divided into three groups with 6 rats each group: 1) sham procedure, 2) PH without PRP administration, and 3) PH with PRP administration. IL-6 levels were examined from blood samples taken from the right atrium on the second day after PH. Results: IL-6 levels in the sham procedure group were relatively equal to the IL-6 levels in the PH group (4.55 ± 0.84 ng/L; 3.80 ± 0.81 ng/L) meanwhile the PH + PRP group was 5.15 ± 0.79 ng/L. However, IL-6 levels in the PH and PH + PRP groups showed significant differences. Conclusion: Administration of PRP can increase IL-6 levels on Wistar rats with partial hepatectomy.