The governments of Indonesia and Malaysia have decided to cooperate in eradicating drug trafficking in the border area of North Kalimantan – Sabah, which is one of the domains of transnational crime which is quite difficult to eradicate. North Kalimantan itself is one of the areas that are weak under the supervision of the Indonesian government, this has resulted in massive drug smuggling efforts by international drug networks that enter through the Sabah region to North Kalimantan and are then circulated in major cities in Indonesia. Based on this, this research was conducted to describe the pattern and form of Indonesia-Malaysia cooperation in eradicating drug trafficking in the border area of North Kalimantan - Sabah. This research was conducted qualitatively with the case study method. In determining the informants, selected purposively snowball to get in-depth information from one informant and scroll to other informants. Research shows that the pattern of cooperation between Indonesia and Malaysia in eradicating drug trafficking in the border area of North Kalimantan - Sabah has been formed through cooperation in the form of information exchange and joint border surveillance patrols on land and sea. However, even so, the pattern that has been formed is still not effective because there are still obstacles found such as obstacles to managing land and sea borders, inadequate facilities and infrastructure, lack of community participation, and limited law enforcement officers and their supporting tools. On the other hand, it is found that the complexity of international drug network actors and also the lack of commitment to cooperation between parties to continue information related to drug smuggling efforts from international drug networks so that the number of smuggling and drug trafficking on the border of North Kalimantan - Sabah is still quite high.