This study investigated “The Influence of Home management practices and Family Environment on the Career Choices of Students in Calabar Municipality, Cross River State, Nigeria”. Indicators of Family Environment such as absence of parents, domestic violence in family, family disharmony and physical and mental illness and Home economics (home management practices) were used to test the relationships between home economics, family environment and Career Choices of Students. The descriptive survey research design was used and the sample was made up of 140 students who were selected from ten secondary schools owned by government and privately owned Calabar municipality of Cross River State. The instrument used for data collection was a questionnaire. The overall reliability of the instrument stood at 0.712 which implied that majority of the students were consistent in their responses. In data analysis, a pre-designed PAST 3 software database with in-built consistency and validation checks were used to enter the data. Further consistency, data range and validation checks were also performed in SPSS version 27 to identify invalid codes. The data were analyzed using frequency counts, percentages and Pearson test to establish the relationship between family environment and career choices of student. The findings indicated that: there was a significant and positive relationship between parental absence and students career choices. Findings equally affirmed that there was a significant and positive relationship between domestic violence in family and career choices of students. Similarly, the findings equally revealed that there was a significant and positive relationship between physical and mental illness and career choices of secondary school students as well as a significant and positive relationship between family disharmony and career choices among secondary school students in Calabar Municipality. Based on the findings, it was recorded that school Counselors should guide students so that they can choose careers base on their personality trait and interest. This will help students to gain career satisfaction