Introduction: One of the key factors contributing to surgical site infections is suture material. The surgical site may be shielded from various infections by a suture material with improved wound healing capabilities. Sutures may hinder the healing of wounds in periodontics and other surgical specialties. Numerous variables, including knot design, tensile strength, and compressive suture strength, affect the strength of the sutures. The two most often used biodegradable polymers are PGA and VICRYL. Quercetin is one of the bioflavonoids that is most frequently used to treat metabolic and inflammatory diseases. It is famous for having antioxidant, vasodilator, and anti-inflammatory qualities. Modern pharmacology makes extensive use of caffeine, a plant alkaloid. Our aim is to evaluate the effects of caffeine and quercetin on absorbable sutures.