Background: Type-2 diabetes mellitus is recognized as a key non-communicable disease affecting over 425 million people globally, with only half of them currently diagnosed. One key indicator of mortality associated with type-2 diabetes is poor adherence to the prescribed medication. Diabetes is a growing medical problem and the costs to society are great and rising. The recent report formed by International Diabetes Federation Diabetes Atlas values that there are presently 387 million people alive with diabetes globally in 2014, a 105% rise from its last report in 2011 with the highest number of people living in the western pacific. Influential factors causing poor adherence to antidiuretic medications and self-care practices among diabetes mellitus (DM) patients have not been reported before in Saudi Arabia. Currently, one in every 11 adults worldwide is living with the condition with 90% of these being type II diabetes patients. The past three decades have recorded a distressing rise in the cases of diabetes mellitus, resulting in quadrupling of the cases. Aim of the study: To assessment the influential factors associated with medication-non adherence and self-care practices among diabetes mellitus patients in Saudi Arabia 2022. Method: cross sectional study conducted at outpatient clinics in diabetes mellitus centers in Saudi Arabia in Sample population consists of Saudi out patients aged 30 <60 years attending. Our total participants were (200). Results:. Show regarding the education status the majority of the respondents tertiary were (62.0%) but secondary were (15.0%), regarding the residence the majority of the respondents urban were (65.0%) while rural were (35.0%), the distance to health facility the majority of the respondents ≥ 30 km were (34.0%) while 10-19 km were (28.0%) while 20-29 km were (17.0%), while less than10 km were (21.0%), regarding the marital status the majority of them married were (65.0%) while single were (22.0%) but divorced were (13.0%), regarding the salary satisfaction the most of participant sufficient were (62.0%). Conclusion: In previous research's it was found that the majority of participants were not adherent to anti-diabetes medication. Non-adherence to medication was associated with younger age and low level of education. Interventions to improve adherence should target younger and newly diagnosed patients through aggressive counseling to address healthy self-management behavior's.