Background/Purpose: Anemia is the most common hematological disorder around the globe. This study evaluated whether anemia patients had specific oral manifestations based on the classification by Mean Corpuscular Volume and Red Cell Volume Distribution Width Methods: The hematological screening includes estimations of red blood count, hemoglobin %, mean corpuscular volume, mean corpuscular hemoglobin, hematocrit, red cell distribution width, ferritin, iron, total iron binding capacity, vitamin B12, liver function tests, and kidney function tests and anemia classified and matched with oral manifestation. Results: In the study, the occurrence of oral signs and symptoms could not be correlated with the distribution of subjects because of the overlap of oral manifestations in different causes of anemia. The hemoglobin % was significant with a p-value of 0.001 which means that hemoglobin % has an important role in the occurrence of anemia. The Mean corpuscular volume in diseases was found to be statistically significant, with a p-value of 0.001 which means that it is necessary for the classification of different types of anemia. The standard deviation of red cell distribution width values in diseases was found to be statistically significant, with a p-value of 0.001 which means that it is important for the classification of different types of anemia.