Nutrients are one of the environmental factors that constantly interact with the human genome. Various nutrients present in the food acts as cofactors in various metabolic pathways, thus seem to influence the processes involved in DNA repair and metabolism. The individual’s genotype determines the response to a particular nutrient whereas the nutrient present in food influences the development of phenotype. In the recent years, there has been a growing interest to utilise the precision nutrition approach for the prevention, management and treatment of obesity, which takes into consideration the interaction between food and the genome. It is quite evident that awareness and popularity about genetic testing for personalised nutrition is gaining momentum. Consumer attitudes and perceptions towards genetic testing to determine the risks of a predisposition to various diseases have already been examined by several studies, consumer acceptance of personalised nutrition have not been studied in the Indian population till date. The responses towards perceived advantages of receiving DNA based dietary advice were ease of understanding and specificity of the diet advice, which was the most frequently reported theme (57.5%), followed by more personalised and enjoyable (22.4%) and reduced costs due to disease prevention (20.1%). It can be concluded that individuals were optimistic and perceived many advantages of nutrigenetic testing. Our study supports that the population is optimistic and willing to adopt genetic tests for personalised nutrition recommendations. We compared the difference in the phenotype between participants receiving nutrigenetic recommendations vs generic standardised recommendations. BMI and waist circumference at 30 days, 60 days, 90 days were measured and they were followed up at 120 days. After 120 days of follow-up individuals in the intervention group were more likely to have maintained some weight loss (82%) than those in the comparison group (21%) .