Background: Gallbladder perforation represents a critical condition characterized by the rupture or puncture of the gallbladder wall, leading to the leakage of bile and potentially causing severe complications. This study aims to shed light on our institution's clinical experience in managing cases of gallbladder perforation, drawing upon a wealth of accumulated expertise and intricate patient encounters. Methods: In this prospective study, a total of 45 patients were included in the study strictly as per the inclusion criteria of the study. These patients were comprehensively evaluated for numerous parameters to meet the objectives of the study. Results: The study showed diverse age distribution, with a higher proportion in the 51-60 years age group and slightly more female patients. Prevalent comorbidities included diabetes (42%) and hypertension (28.9%), emphasizing the need for comprehensive care. Calculous cholecystitis was the main cause (88.9%), and Type II gallbladder perforation was the most common (75.6%). Percutaneous drainage was the primary treatment (84.4%), followed by laparoscopic cholecystectomy (8.9%) and emergency laparotomy (6.7%). Hospitalization durations varied, with a significant number requiring 7-10 days. Complications such as peritonitis, sepsis, cholecystoenteric fistula, and pleural effusion highlighted the risks associated with gallbladder perforation. Conclusion: The study comorbidities like diabetes and hypertension were prevalent. Calculous cholecystitis was the main cause, with Type II gallbladder perforation being common. Percutaneous drainage was the primary treatment, with varying hospitalization durations. Complications highlighted the risks. Findings contribute to knowledge, emphasizing the need for a multidisciplinary approach.