Several changes to the coronavirus 2 linked to severe acute respiratory syndrome have increased the disease's transmission and death rates globally (COVID-19) (SARS-CoV-2). Despite the creation of multiple vaccines, a considerable portion of the global population continues to be at high risk for sickness. The 3D x-ray crystal structure of spike protein RBD with 2-acetamido-2-deoxy-Beta-D-glucopyranose derivative (6YZ5.pdb), H11-D4 complex with SARS-CoV-2 RBD, Macromolecule was retrieved from protein data bank and was then further prepared using the protein preparation wizard of Schrödinger suite 2020-1. In the present study have been performed to explore the binding modes of super natural compounds (SNP) against SARS-CoV-2 spike protein target by in-silico approach.